In order to elicit the pharmacological action in the body the release rate and onset of action is extremely important for different dosage forms. To determine the biological activity of product the rate and extent of availability of drug into systemic circulation is essential. Drug products are said to be bioequivalent, when two or more chemically equilent drug products are not significantly in bioavailability characteristics when administered in same dose under similarly experiment conditions. The other type of equilences is chemical, therapeutic and pharmaceutical equilences. In- vitro equilency testing studies are generally conducted by comparing the dissolution profiles performers of dosage forms of amoxicillin trihydrate tablets using dissolution equipment. These tests are important for verification of the batch-to-batch profile, uniformity with respect to dissolution for the same product in the industry. In the present study in vitro equilency tests are proposed to conduct in vivo of difference in manufacturing processes adopted by the difference pharmaceutical manufactures, influence of process variables, on drug release, the difference in type and quantities of excepients used in the formulation and various physico chemical factors of the drugs and excepients used in the design of the dosage form. As there is increasing in the number of products of same drug in different industries and in different dosages.
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